Course syllabus adopted 2021-02-26 by Head of Programme (or corresponding).
Overview
- Swedish nameTissue engineering
- CodeKPO065
- Credits7.5 Credits
- OwnerMPBIO
- Education cycleSecond-cycle
- Main field of studyBioengineering, Engineering Physics
- DepartmentCHEMISTRY AND CHEMICAL ENGINEERING
- GradingTH - Pass with distinction (5), Pass with credit (4), Pass (3), Fail
Course round 1
- Teaching language English
- Application code 08111
- Maximum participants40
- Open for exchange studentsYes
Credit distribution
Module | Sp1 | Sp2 | Sp3 | Sp4 | Summer | Not Sp | Examination dates |
|---|---|---|---|---|---|---|---|
| 0104 Examination 7.5 c Grading: TH | 7.5 c |
|
In programmes
- MPBIO - BIOTECHNOLOGY, MSC PROGR, Year 1 (compulsory elective)
- MPBME - BIOMEDICAL ENGINEERING, MSC PROGR, Year 1 (compulsory elective)
- MPBME - BIOMEDICAL ENGINEERING, MSC PROGR, Year 2 (elective)
Examiner
Paul Gatenholm- Professor Emeritus, Applied Chemistry, Chemistry and Chemical Engineering
Eligibility
General entry requirements for Master's level (second cycle)Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.
Specific entry requirements
English 6 (or by other approved means with the equivalent proficiency level)Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.
Course specific prerequisites
Courses in chemical and biological engineering.Aim
Although the lives of thousands of people are saved by reconstructive surgeons, many people are still waiting for organ donations. Reconstructive surgery became, in the last decade, a new discipline - tissue engineering with focus on the fabrication of living replacement parts for the body in the laboratory. Tissue engineering includes biology, chemistry, material science, engineering, immunology and transplantation. This course provides a general understanding of tissue growth and development and the tools and theoretical information needed to design tissues and organs.Learning outcomes (after completion of the course the student should be able to)
- Describe the principles of tissue engineering
- Describe clinical applications of tissue engineered products in regenerative medicine
- Define the importance of scaffold materials in tissue engineering with focus on surface-, mechanical- and biological properties
- Describe different scaffold materials and define in what applications these materials can be applied
- Describe several scaffold fabrication techniques such as electrospinning and solvent casting/particulate leaching
- Describe different biofabrication methods of tissue with focus on additive manufacturing, and particularly, the 3D Bioprinting technology
- Describe the early events that occur in tissue development, from the first division in the egg to the migration of cells to form the different germ layers
- Describe the formation of different organs due to gene regulations and cell signaling
- Describe the equipment used in cell culturing laboratory
- Describe the basic components of the Extracellular Matrix (ECM) and its importance in tissue engineering
- Describe the signaling process between cells and cell-ECM and its potential outcomes on cellular fate
- Define the importance of bioreactors in tissue engineering
- In theory, design a bioreactor and put emphasis on its requirements for cultivation of tissue engineered products
- Define the ethical and regulatory aspects of tissue engineering in clinical applications
- Develop a project within the field of tissue engineering which seeks to solve unmet clinical needs
Content
The following topics will be covered: Introduction Cell biology, the basis of growth and differentiation, growth factors, In vitro and in vivo control of tissue development, polymer scaffolds and biofabrication techniques, stem cells and their differentiation, bioreactors, ethical and regulatory aspects of tissue engineering, translation to clinic.
Organisation
The course consists of lectures, seminars, laboratory- and project work. Laboratory work will include an introduction to sterile technique, cell seeding laboratory and tissue biofabrication. In the group projects, students will prepare grant proposals for tissue engineering of selected tissue/organs for unmet clinical needs. The written proposal will be submitted and presented orally.
Literature
Tissue engineering; Clemens van Blitterswijk, Jan De Boer, 2:nd edition Academic Press 2014
Examination including compulsory elements
Laboratory exercises, project report and project presentation. Individual active participation is required in all group work. Grading will reflect the level of achievement of the whole group, with individual adjustment of grades from the group grade applied when relevant.
The course examiner may assess individual students in other ways than what is stated above if there are special reasons for doing so, for example if a student has a decision from Chalmers on educational support due to disability.