Course syllabus for Advanced molecular biology

Course syllabus adopted 2020-02-19 by Head of Programme (or corresponding).

Overview

  • Swedish nameAvancerad molekylärbiologi
  • CodeKMG037
  • Credits7.5 Credits
  • OwnerMPBIO
  • Education cycleSecond-cycle
  • Main field of studyBioengineering
  • DepartmentKEMI OCH MOLEKYLÄRBIOLOGI (GU)
  • GradingTH - Pass with distinction (5), Pass with credit (4), Pass (3), Fail

Course round 1

  • Teaching language English
  • Application code 08125
  • Maximum participants20
  • Open for exchange studentsNo

Credit distribution

0114 Examination 7.5 c
Grading: TH		7.5 c
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Examiner

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Eligibility

General entry requirements for Master's level (second cycle)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.

Specific entry requirements

English 6 (or by other approved means with the equivalent proficiency level)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.

Course specific prerequisites

Undergraduate profile (BSc) with courses in cell and molecular biology, biochemistry, and applied microbiology.

Aim

This course shall focus on a detailed understanding of gene regulation and protein dynamics with particular emphasis on human diseases.

Learning outcomes (after completion of the course the student should be able to)

At the end of the course students should be able to:
  • Describe the dynamic behavior of the cytoskeleton and explain how this occurs
  • Explain the importance of protein quality control for cellular health
  • Describe the different families of molecular chaperones and their mechanisms of action
  • Describe how cancer cells are motile and explain the involvement of the cytoskeleton
  • Describe the cell biology of breast cancer
  • Describe the cell cycle and its regulation with focus on chromosome segregation and checkpoints
  • Describe the basic mechanisms for the major intracellular signaling pathways
  • Explain cellular regulation at the RNA level
  • Describe the role of oncogenes and tumor suppressor genes in cancer, the principles of cancer therapies and mechanisms of drug resistance
  • Describe the molecular process of meiotic cell division in mammals.
  • Describe the hierarchical molecular process and function of meiotic homologous recombination.
  • Describe how telomere length is maintained.
  • Describe how telomere is molecularly reconstituted during meiosis.

At the end of the lab classes students should be able to:

  • Carry out staining procedures for mammalian cells and identify normal and disrupted cytoskeletal structures.

Content

  • Eukaryotic cell cycle
  • Intracellular regulation
  • Cytoskeleton
  • Molecular chaperones
  • Cancer cell biology
  • Meosis
  • Telomere structure and function

Organisation

Lectures, laboratory classes (attendance is compulsory), seminars

Literature

No set book but Lodish et al., Molecular Cell biology or Alberts et al., Molecular Biology of the Cell would be useful. Recommended reading lists and handouts will be provided.

Examination including compulsory elements

Students must pass the written examination, complete the laboratory classes and laboratory reports.