Course syllabus for Radiopharmaceutical chemistry

The course syllabus contains changes
See changes

Course syllabus adopted 2020-05-20 by Head of Programme (or corresponding).

Overview

  • Swedish nameRadiofarmaceutisk kemi
  • CodeKBT221
  • Credits7.5 Credits
  • OwnerMPMCN
  • Education cycleSecond-cycle
  • Main field of studyBioengineering, Chemical Engineering with Engineering Physics, Chemical Engineering, Engineering Physics
  • DepartmentCHEMISTRY AND CHEMICAL ENGINEERING
  • GradingTH - Pass with distinction (5), Pass with credit (4), Pass (3), Fail

Course round 1

The course round is cancelled. For further questions, please contact the director of studies
  • Teaching language English
  • Application code 30122
  • Maximum participants25
  • Minimum participants8
  • Block schedule
  • Open for exchange studentsYes

Credit distribution

0115 Laboratory 2.5 c
Grading: UG		2.5 c
0215 Examination 5 c
Grading: TH		5 c

In programmes

Examiner

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Eligibility

General entry requirements for Master's level (second cycle)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.

Specific entry requirements

English 6 (or by other approved means with the equivalent proficiency level)
Applicants enrolled in a programme at Chalmers where the course is included in the study programme are exempted from fulfilling the requirements above.

Course specific prerequisites

Basic Chemistry (University level), Inorganic chemistry, Nuclear chemistry

Aim

The overall aim of the course is to provide understanding on the use of radioactive nuclides in nuclear medicine; the use of radionuclides for diagnosis and therapy; the production and properties of radionuclides used for medical purposes; the synthesis of radiolabeled compounds; production and test of radiopharmaceuticals and practical labeling work along with study visits in relevant environment (pharmaceutical company and hospital). The level of understanding should be such that the students in their profession as engineers should be able to participate in discussions regarding the choice of a radionuclide to be used in medical applications as well as the purification and labeling work and further to ensure the quality control necessary for the next step in licensing of a drug or application.

Learning outcomes (after completion of the course the student should be able to)

  • Describe the basics of radioactive nuclides in nuclear medicine.

  • Describe and exemplify radionuclides for diagnosis and therapy.
  • Describe and exemplify production and properties of radionuclides used for medical purposes.
  • Describe and practically and theoretically exemplify the synthesis of radiolabeled compounds.
  • Describe the basics of production and test of radiopharmaceuticals.
  • Carry-out hands-on laboratory work for practical labeling work.

Content

The course comprises on interaction of radiation with matter, microdosimetry, radionuclide production, radionuclide generators, design of a radiopharmacy lab, how to work in a radiopharmacy lab, radiolabeling, quality control, factors which affect the integrity of radiopharmaceuticals, legislation, practical issues (documentation, labeling, transport, etc), waste management in radiopharmacy, pharmacology, pharmacokinetics and metabolism of radiopharmaceuticals, diagnostic and therapeutic applications, PET and heavy ion therapy.

Organisation

The course consists of a series of lectures, two laboratory projects in collaboration with GU and Sahlgrenska as well as a study visit to the pharmaceutical research facility of the company AstraZeneca, Mölndal. For fewer participants in the course than 8, it will be given in a different format. The number of lectures is reduced, but consultation sessions and on-line seminars are given. Laboratory exercises will be limited depending on the number of participants.

Literature

Charles B. Sampson “Textbook of Radiopharmacy – Theory and Practice, 2nd enlarged edition”, Gordon and Breach Publishers, or other editions as well.
Gopal B. Saha, Fundamentals of Nuclear Pharmacy, Fifth edition, ISBN 0-387-40360-4, Springer.

Examination including compulsory elements

The examination is based on a written exam in two parts (questions and calculations) and approved oral or written presentation of the two laboratory events.

The course syllabus contains changes

  • Changes to course rounds:
    • 2020-05-18: Cancelled Changed to cancelled by UOL
      [Course round 1] Cancelled