Wednesday, March 19
10:00 - 11:00 Registration & Coffee
Session 1
Chair: Ludmilla Morozova-Roche
11:00 - 11:10 Welcome (Elin Esbjörner & Pernilla Wittung-Stafshede) - 10 min
11:10 - 11:50 Plenary talk: Sheena Radford "Watching Amyloid Form: From Test Tubes to Tissues" - 40 min
11:50 - 12:20 Sofie Nyström "Crosstalk between virus amyloids and human protein misfolding in neurodegenerative disease" - 30 min
12:20 - 12:35 Jacob Aunstrup Larsen "How do amyloid fibrils grow? – Mechanistic insights from Φ-value analysis" - 15min
12:40 - 14:00 Lunch & Poster session #1 - 80min
Session 2
Chair: Per Hammarström
14:00 - 14:30 Matthew Horrocks "Exploring protein aggregation at the single-molecule Level" - 30 min
14:30 - 14:45 Jeremias Widmann "Structural and kinetic insights into metabolite self-assembly" - 15 min
14:45 - 15:00 Tinna Palmadottir "Morphology dependent interaction of free α-synuclein monomers and fibrils" - 15 min
15:00 - 15:45 Celine Galvagnion-Bull "Lipidomic Profiling Reveals Shared and Distinct Pathological Signatures in Sporadic Parkinson's Disease and GBA Mutation Carriers" - 30 min
15:30 - 16:00 Coffee break - 30 min
Session 3
Chair: Christoffer Lendel
16:00 - 16:30 Sofia Lövestam "Molecular mechanisms of tau filament formation" - 30 min
16:30 - 16:45 Chiara Morelli "The role of RNA in hnRNPA1A phase transitions" - 15 min
16:45 - 17:00 Niklas Österlund "Structural studies of Amyloid-β peptide oligomers at oligomer-specific resolution" - 15 min
17:00 - 17:05 Information about dinner
18:00 Dinner at Universeum Science Museum
Thursday, March 20
Session 4
Chair: Gunilla Westermark
09:00 - 09:30 Daniel Otzen "Antibodies targeting the cytotoxic α-synuclein oligomer" - 30 min
09:30 - 09:45 Fritjof Havemeister "Aggregation and Stability of α-Synuclein Amyloid Fibrils: Implications for Pathology in Parkinson’s disease" - 15 min
09:45 - 10:10 Jinghui Luo "Understand the molecular root causes of neurodegeneration by X-ray and Nanopore techniques" - 25 min
10:10 - 10:40 Vito Fodera "Heterogeneity in Amyloid Aggregation" - 30min
10:40 - 11:10 Coffee break - 30 min
Session 5
Chair: Sara Linse
11:10 - 11:40 Astrid Gräslund "Biophysical studies of the Amyloid β peptide: interactions, structure conversions and aggregation" - 30 min
11:40 - 12:05 Ji-Xin Cheng "Vibrational Photothermal Microscopy and Applications to Protein Analysis" - 25 min
12:05 - 12:35 Michal Maj "Mechanistic and Structural Insights into hIAPP Amyloid Polymorphism" - 30 min
12:35 - 14:00 Lunch & Poster session #2 - 90 min
Session 6
Chair: Daniel Otzen
14:00 - 14:30 Louise Serpell "Sparking protein misfolding and neuronal damage in Alzheimer’s disease" - 30 min
14:30 - 14:45 Andreas Carlsson "Co-aggregation of the tau peptide and the human chaperone DNAJB6b" - 15 min
14:45 - 15:00 Ajay Pradhan "Amyloid Beta-Induced Changes in Spontaneous Neuronal Firing and Presynaptic Glutamate Release in hiPSC-Derived Cortical Neurons" - 15 min
15:00 - 15:30 Anders Olofsson "Misfolding of transthyretin in vivo is controlled by the redox environment and macromolecular crowding" - 30 min
15:30 - 16:00 Coffee break - 30 min
Session 7
Chair: Sofie Nyström
16:00 - 16:30 Gian Gaetano Tartaglia "The effect of RNA on protein phase separation and transition" - 30 min
16:30 - 16:45 Cecilia Mörman "Molecular chaperone-mediated regulation and inhibition of Tau phase separation, fibrillation, and toxicity" - 15 min
16:45 - 17:00 Darius Sulskis "Structural Insights into Alpha-Synuclein Amyloid Fibril Polymorphism via Cryo-EM" - 15 min
17:00 - 17:30 Michele Vendruscolo "Drug design for undruggable targets using AI" - 30 min
18:00 - 20:00 Buffet dinner & Poster session #3 - 120 min
Friday, March 21
Session 8
Chair: Axel Abelein
09:00 - 09:30 Claudio Gomes "Chaperone-mediated neuroprotection against protein aggregation" - 30 min
09:30 - 09:45 Maria Andreasen "Polymorphism in Functional Amyloids of PSMα1" - 15 min
09:45 - 10:00 Tina Jacob "Liquid-Liquid phase separated Tau colocalizes with Aβ oligomers and stabilizes them" - 15 min
10:00 - 10:30 Sara Linse "Towards a thermodynamic understanding of amyloid solubility enhancement by chaperones" - 30 min
10:30 - 11:00 Coffee break
Session 9
Chairs: Elin Esbjörner & Pernilla Wittung-Stafshede
11:00 - 11:30 Lars Lannfelt "Lecanemab – from a mutation to a treatment for Alzheimer’s disease" - 30 min
11:30 - 12:10 Plenary 2: Jeff Kelly "The Scientific Origins of Drugs that Slow Neurodegeneration & the Structure–Proteotoxicity Relationship that Emerges from Clinical Studies" - 40 min
12:10 - 12:40 Panel discussion - 20 min
12:40 - 13:00 Concluding remarks - 30 min
13:00 - 14:00 Lunch & Goodbye